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Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer’s disease early phenotypes.


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Cholesterol-24-hydroxylase (CYP46a1) inhibition and accumulation of neuronal cholesterol in hippocampus leads to amyloid production, neurodegeneration and paves the way for Alzheimer’s disease


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Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology


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Cyp46-A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s Disease 


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Neuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis

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CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington’s Disease

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Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia
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