New results about how impaired brain cholesterol metabolism leads to neurodegeneration

By July 18, 2017Non class

Impairment in cholesterol metabolism is associated with many neurodegenerative disorders including Alzheimer’s disease (AD). However, the lipid alterations underlying neurodegeneration and the connection between altered cholesterol levels and AD remains not fully understood.

In a new publication, Cartier et al. demonstrated that major membrane lipids, sphingolipids and specific enzymes involved in phosphatidylcholine and sphingolipid metabolism, were rapidly increased in the hippocampus of AAV-shCYP46A1 injected mice.

In conclusion, neuronal cholesterol accumulation induced by Cyp46a1 down-regulation in mouse hippocampus disrupts brain lipid homeostasis.

See the publication